Nature

Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum

Figure 1: Four different strategies for 7-ADCA production. Figure 5: Genetic map of the plasmid pALC88 used to introduce ring expansion activity (DAOCS) into A. chrysogenum ΔcefEF. Fermentation ...
Nature

Clinical and genetic characterization of 16q-linked autosomal dominant spinocerebellar ataxia in South Kyushu, Japan

We had reported that this disease locus was telomeric to the puratrophin-1 gene. 8 To clarify the disease locus in these patients, we reexamined the disease haplotype using microsatellite markers and ...
ascopubs.org

A phase II trial of CPT-11 in patients (pts) with advanced gastric or gastroesophageal (GE) junction adenocarcinoma (ADCA): A clinical and pharmacodynamic evaluation. A North ...

4026 Background: The goals of this study were to determine the response rate (RR) and toxicity of CPT-11 as first-line therapy for gastric and GE junction ADCA, to describe the overall survival (OS) ...