Adverse effects of low-dose MTX in patients with RA are related to folate antagonism and/or folate deficiency. Folate supplementation, in the form of folic acid or folinic acid, is often ...

Folinic acid is an active form of folate, while folic acid must be converted in the body. Leucovorin (folinic acid) is prescribed for methotrexate toxicity, megaloblastic anemia, and advanced ...

Disclosure: The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials ...

In July 2022, the US Food and Drug Administration (FDA) expanded the labeling of Krystexxa (pegloticase; Horizon Therapeutics), a PEGylated uric acid-specific enzyme, to include coadministration with ...

Methotrexate is one of the oldest and most cost-effective medicines available for rheumatoid arthritis (RA). Its also one of the most commonly used RA therapies. Heres what to know about this drug if ...

A recent survey highlighted that increased dietary intake of folic acid causes adverse health effects by promoting angiogenesis, inflammation, and neurotoxicity. Study: How Increased Dietary Folic ...

This article was reviewed by Lynn Marie Morski, MD, JD. Folic acid is an essential nutrient you’ve likely seen on food labels or vitamin bottles — often targeting pregnant women (since it helps ...

Folic acid is essential to help you prevent neural tube defects during pregnancy. Taking folic acid may help lower your risk of stroke and slow age-related macular degeneration. Folic acid is the ...

A new review reveals how folic acid can act as both a friend and foe in breast cancer, protecting at moderate doses, but potentially fueling tumor growth when intake is excessive or genes go awry.