Independent Data Monitoring Statistician reaffirmed current sample size to remain at N=160 The trial has reached 75% of the targeted enrollment, and topline results continue to be expected in the ...
Asymptotically, sample proportions from a multinomial distribution converge in distribution to a multivariate normal distribution with a singular negative product correlation structure. Based on this ...
Sample size determination is an important component of study design and can frequently be addressed using the multinomial probability model. The sample size determination procedures of Tortora and ...
Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...
Biogen has spooked investors by disclosing midstudy changes to its late-phase Alzheimer’s program. The biotech is adding 510 patients to the phase 3 aducanumab trials after seeing more “variability” ...
Conflicting findings are often reported in microbiome association studies, which could be due to insufficient sample sizes and numerous confounders. A new study, utilizing two large-scale human ...