Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

At the end of 2023, the FDA approved Casgevy for sickle cell disease, its first approval for a therapeutic that used the genome editing tool clustered regulatory interspaced palindromic repeats ...

At the core of each of our cells, the DNA molecule is constantly changing its configuration. When it twists or unfolds, it determines which genes are activated at each moment. "We have shown that the ...

Using high-resolution cryo-electron microscopy (cryo-em), researchers from Durham University, Jagiellonian University, and the John Innes Centre uncovered unprecedented detail of gyrase’s action on ...